We use RNA sequencing from neck tissues and advanced phenotyping to identify new treatment targets for chronic pain.

We aim to create the scientific foundation that will empower pain researchers to approach the problem of treating pain deeply rooted in a fundamental understanding of the first neurons and first synapses in the human pain pathway.

We aim to identify molecular pathways potentially involved in the pathophysiology of chronic low back pain and fibromyalgia through the application of metabolomics in thoroughly phenotyped individuals.

This pilot study aims to explore the metabolomics profile of the cerebrospinal-spinal fluid, blood and urine in patients with spinal muscular atrophy (SMA). This study will generate information and data critical to developing future hypothesis-driven research to clarify the mechanisms of pain in SMA.

Our Hub is a network that provides scientific leadership and administrative oversight of high-quality Phase 2 clinical trials and biomarker validation studies on pain, as part of the NIH’s HEAL Initiative within the Early Phase Pain Investigation Clinical Network (EPPIC-Net).

Within the EPPIC-Net: A multi-center, placebo-controlled, crossover study that aims to evaluate CNTX-6970 as a new treatment for knee osteoarthritis pain.

Surgery for breast cancer causes chronic pain in 25-60%. The goal of this multi-centric study is to test the effectiveness of ketamine infusion during and few hours after surgery to reduce the occurrence of chronic pain after breast surgery.

This clinical trial in patients with knee osteoarthritis pain aims to evaluate the comparative-effectiveness of conservative behavioral and non-opioid pharmacological treatments and, among non-responders, the benefits of nonsurgical procedural interventions.

The Clinical Learning, Evidence And Research (CLEAR) Center aims to improve the health of patients with musculoskeletal conditions by providing scientifically rigorous methods and resources for clinical research towards a learning healthcare system.

SPINE-WORK is a network of researchers interested in spine pain and force-based manipulations. The major goal is to lay the intellectual groundwork for improved treatment of low back and neck pain via force-based manipulations.

We conduct a multi-site project in urinary stone disease to study pain and associated disorders caused by ureteral stent placement. The aim is to understand and mitigate ureteral stent-associated pain and urinary symptoms.

The goal of this multi-site project is to assess the efficacy and safety of a novel approach utilizing a nerve block to the PPF to mitigate opioid use requirements and improve headache pain control in patients with aneurysmal subarachnoid hemorrhage.