Identifying novel therapeutic targets for chronic neck pain
The lack of understanding of the molecular mechanisms that drive chronic neck pain has hampered the development of effective mechanism-specific therapeutics. We use RNA sequencing on joint and nerve tissues of patients with chronic and acute neck pain, coupled with computational biology methods and careful patient phenotyping, to examine how molecules produced in the diseased tissue drive chronic pain. Our work has the potential to reveal new molecular targets for future drug development.
Michele Curatolo, University of Washington, Seattle (contact)
Christoph Hofstetter, University of Washington, Seattle
Ted Price, University of Texas at Dallas